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SASInstitute A00-282 Exam Syllabus Topics:

Section	Weight	Objectives
Clinical Trials Data Structures	10%	- CDISC standards: SDTM, ADaM - Define.xml and dataset specifications - Clinical domain structures
Apply Statistical Procedures for Clinical Trials	15%	- PROC MEANS, FREQ, TABULATE - Basic statistical analysis for clinical data
Validate Clinical Trial Data Reporting	20%	- Programming validation techniques - Use PROC COMPARE and log review - Validation principles
Clinical Trials Process	5%	- Clinical trial lifecycle and protocol - Derive programming requirements from protocol and CRF
Macro Programming for Clinical Trials	15%	- Debugging macros - Macro variables and parameters - Create and call macros
Manage Clinical Trials Data	5%	- Use SQL and dictionary tables - Access and explore clinical datasets - Clean, merge, and subset data
Regulatory Submissions	5%	- Compliance for clinical data reporting - ICH and FDA guidelines
Report Clinical Trials Results	10%	- Produce tables, listings, and figures - PROC REPORT and PROC PRINT
Transform or Summarize Clinical Trials Data	15%	- Derive variables and study days - Data step manipulation - Aggregation and transposition

SASInstitute Clinical Trials Programming Using SAS 9.4 Sample Questions:

1. What is the primary purpose of programming validation?

A) Justify the means used to accomplish the outcome of a program and ensure its accurate representation of the original data.
B) Efficiently ensure any logic errors are discovered early in the programming process.
C) Ensure that the output from both the original program and the validation program match.
D) Document all specifications pertaining to programmed output and ensure all were reviewed during the programming process.

2. The data set CM has eight variables including CMTRT and is sorted by STUDYID USUBJID CMSEQ.
DATA_BB is created by selecting records from CM where the character string "BLOCKER" is included in CMTRT.

Which program was used to produce WORK.DATA_BB?

A) data data_bb;
set cm (where=(find(cmtrt,'BLOCKER','i')>0));
by usubjid CMSTDTC;
run;
B) data data_bb;
set cm (keep=usubjid cmstdtc cmtrt);
by usubjid CMSTDTC;
where cmtrt in('BLOCKER');
run;
C) proc sort data=cm out=data_bb (keep=usubjid cmstdtc cmtrt);
by usubjid CMSTDTC;
where cmtrt in('BLOCKER');
run;
D) proc sort data=CM (keep=usubjid cmstdtc cmtrt) out=data_bb;
by usubjid CMSTDTC;
where cmtrt contains 'BLOCKER';
run;

3. The following SAS program is submitted:

Which types of variables are DayofMonth, MonthofYear, and Year?

A) DayofMonth, Year, and MonthofYear are character.
B) DayofMonth and Year are numeric. MonthofYear is character
C) DayofMonth, Year, and MonthofYear are numeric.
D) DayofMonth, Year, and MonthofYear are date values

4. This question will ask you to provide lines of missing code.
Given the following SCORE data set:

Variable LOCF contains the imputed score that would replace the missing SCORE value (based on last observation carried forward method).
Which SAS statements complete the program?

A) if first.subject then LOCF = .; if score = . then LOCF = lag(score);
B) LOCF = lag(score); if first.subject then LOCF = .; if score ^= . then LOCF = score;
C) retain LOCF; if first.subject then LOCF = .; if score ^= . then LOCF = score;
D) retain score; if first.subject then LOCF = .; if score ^= . then LOCF = score;

5. The following SAS program is submitted:

What is the value of the variable day when the data step completes?