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American Society of Microbiology ABMM Sample Questions:

1. During a community outbreak of influenza, a public health laboratory performs rapid antigen testing on nasopharyngeal swabs. A test for influenza A is positive, but the influenza B test is negative. Subsequently, RT-PCR is performed on the same sample, and it is negative for both influenza A and B viral RNA. The MOST likely explanation for this discordant result is:

A) The patient was infected with a novel influenza strain not detected by either assay.
B) The rapid antigen test has low sensitivity, resulting in a false positive.
C) The RT-PCR assay has a high limit of detection, missing a low viral load.
D) The rapid antigen test yielded a false positive result, and the RT-PCR was a true negative.

2. The human virome, the collection of viruses that reside in and on the human body, is increasinglyrecognized for its role in health and disease. Which of the following statements regarding the human virome is MOST accurate?

A) The human virome is primarily composed of pathogenic viruses that cause acute infections.
B) Bacteriophages, viruses that infect bacteria, are a significant component of the human gut virome.
C) The human virome is largely independent of the host's immune status.
D) The composition of the human virome is relatively stable over time and is not influenced by environmental factors.

3. A patient with a history of recurrent sinopulmonary infections and bronchiectasis is diagnosed with primary ciliary dyskinesia. Sputum cultures are most likely to persistently grow which of the following organisms?

A) Pseudomonas aeruginosa
B) Streptococcus pneumoniae
C) Haemophilus influenzae
D) Moraxella catarrhalis

4. A patient develops a febrile illness with a diffuse petechial rash after a camping trip. Serological testing reveals a four-fold rise in antibody titer to Rickettsia rickettsii. The vector responsible for transmitting this organism is a:

A) Mosquito
B) Tick
C) Flea
D) Louse

5. A microbiology laboratory is processing a throat swab for the detection of Group A Streptococcus. Culture on sheep blood agar reveals beta-hemolytic colonies. Which of the following tests can be used to presumptively identify Streptococcus pyogenes?

A) Bile esculin hydrolysis
B) Coagulase test
C) Bacitracin susceptibility
D) Catalase test

Solutions: